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Home > Higher Education > Medical > 3D CELL-BASED BIOSENSORS IN DRUG DISCOVERY PROGRAMS
3D CELL-BASED BIOSENSORS IN DRUG DISCOVERY PROGRAMS, 1/e

3D CELL-BASED BIOSENSORS IN DRUG DISCOVERY PROGRAMS, 1/e

WILLIAM S. KISAALITA

ISBN : 9781420073492
Pages : 404
Binding : Paperback
Language : English
Imprint : Taylor & Francis
Trim size : 6" x 9" inches
Weight : 1kg
© year : 2014
List Price : Book Details 695.00
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The book supplies a historical perspective and defines the problem 3D cultures can solve. It also discusses how genomics and combinatorial chemistry have changed the way drug are discovered and presents data from the literature to underscore the less-than-desirable pharmaceutical industry performance under the new paradigm. The author uses results from his lab and those of other investigators to show how 3D micro environments create cell culture models that more closely reflect normal in vivo-like cell morphology and function. He makes a case for validated biomarkers for three-dimensionality in vitro and discusses the advantages and disadvantages of promising tools in the search of these biomarkers. The book concludes with case studies of drugs that were abandoned late in the discovery process, which would have been discarded early if tested with 3D cultures.

 
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